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Found to be upregulated in the HCC microenvironment, agrin promotes cancer cell proliferation and "stiffness" of the tumor tissue, which helps the cancer spread.

A fragment of Collagen XVIII that acts as a potent angiogenesis inhibitor . It prevents the formation of new blood vessels that feed the tumor. Therapeutic Potential 27879.rar

Proteoglycan 4 (PRG4) has shown potential in making current chemotherapy drugs (like sorafenib) more effective by interfering with cancer cell resistance. Found to be upregulated in the HCC microenvironment,