: While lobar intracerebral hemorrhage (ICH) and microbleeds remain central, cortical superficial siderosis (cSS) and convexity subarachnoid hemorrhage are now prioritized. Multiple separate foci of siderosis can now qualify a patient for a "probable CAA" diagnosis on their own.
: The minimum age for applying the criteria has been lowered from 55 to 50 years . : While lobar intracerebral hemorrhage (ICH) and microbleeds
The Boston criteria version 2.0 for cerebral amyloid angiopathy The Boston criteria version 2
: Enlarged fluid spaces in the deep white matter. Key Evolutions in the Next Generation Criteria :
The "next generation" of cerebral amyloid angiopathy (CAA) diagnosis is defined by the , released in late 2022 to replace the 2010 modified criteria. This update shifts the diagnostic paradigm from purely hemorrhagic markers to a more holistic "small vessel disease" profile, integrating white matter signatures. Key Evolutions in the Next Generation Criteria
: For the first time, white matter characteristics are part of the formal criteria. A diagnosis of probable CAA can now be made with just one lobar hemorrhagic lesion if accompanied by either: